Creatine supplementation is beneficial for athletes and fitness enthusiasts engaging in high-intensity, short-duration activities such as weightlifting, sprinting, and high-intensity interval training (HIIT). It supports increased physical performance in successive bursts of short-term, high-intensity exercise when consumed at a daily intake of at least 3g of creatine.

Creatine supplementation can enhance the effects of resistance training on muscle strength in adults over the age of 55. This benefit is achieved when consuming at least 3g of creatine daily in combination with a resistance training program performed at least three times per week.